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The mobility of mitochondria: Intercellular trafficking in health and disease
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SYSNO ASEP 0507981 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The mobility of mitochondria: Intercellular trafficking in health and disease Author(s) Berridge, M.V. (NZ)
Neužil, Jiří (BTO-N) RIDNumber of authors 2 Source Title Clinical and Experimental Pharmacology and Physiology. - : Wiley - ISSN 0305-1870
Roč. 44, DEC 2017 (2017), s. 15-20Number of pages 6 s. Language eng - English Country AU - Australia Keywords bioenergetics ; cancer ; intercellular mitochondrial trafficking ; disease Subject RIV FR - Pharmacology ; Medidal Chemistry OECD category Pharmacology and pharmacy R&D Projects GAP301/10/1937 GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 000418663800003 EID SCOPUS 85030033108 DOI 10.1111/1440-1681.12764 Annotation The view that genes are constrained within somatic cells is challenged by in vitro evidence, and more recently by in vivo studies which demonstrate that mitochondria with their mitochondrial DNA (mtDNA) payload not only can, but do move between cells in tumour models and in mouse models of tissue damage. Using mouse tumour cell models without mtDNA to reflect mtDNA damage, we have shown that these cells grow tumours only after acquiring mtDNA from cells in the local microenvironment resulting in respiration recovery, tumorigenesis and metastasis. Mitochondrial transfer between cells has also been demonstrated following ischaemia-induced injury in the heart and brain and in lung epithelium, and following lung inflammation. In vitro investigations suggest that stem cells may be mitochondrial donors. The ability of mitochondria to move between cells appears to be an evolutionarily-conserved phenomenon, relevant to diseases with compromised mitochondrial function including neurodegenerative, neuromuscular and cardiovascular diseases as well as cancer and ageing. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2020 Electronic address https://onlinelibrary.wiley.com/doi/full/10.1111/1440-1681.12764
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