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HORMONES IN AGEING AND LONGEVITY
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SYSNO ASEP 0507476 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases Author(s) Voller, Jiří (UEB-Q) RID, ORCID
Maková, Barbara (UEB-Q)
Kadlecová, Alena (UEB-Q) ORCID
Gonzalez, Gabriel (UEB-Q) ORCID
Strnad, Miroslav (UEB-Q) RID, ORCIDNumber of authors 5 Source Title HORMONES IN AGEING AND LONGEVITY. - Cham : Springer, 2017 / Rattan S ; Sharma R - ISSN 2199-9007 - ISBN 978-3-319-63001-4 Pages roč. 6 (2017), s. 311-335 Series Healthy Ageing and Longevity Number of pages 25 s. Number of copy 2100 Number of pages 338 Publication form Print - P Language eng - English Country CH - Switzerland Keywords Cytokinin ; Kinetin ; Kinetin riboside ; antiproliferative activity ; induced differentiation ; huntingtons-disease ; biological-activity ; cell-proliferation ; adenosine receptor ; oxidative damage ; Zeatin ; Benzyl adenine ; Topolin ; Skin ; Anti-aging ; Anti-inflammatory activity ; Neuro protection Subject RIV EB - Genetics ; Molecular Biology OECD category Oncology R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA17-14007S GA ČR - Czech Science Foundation (CSF) Institutional support UEB-Q - RVO:61389030 UT WOS 000432246600015 DOI 10.1007/978-3-319-63001-4_14 Annotation Cytokinins are phytohormones that regulate plant growth, development and senescence. Experiments both in vitro and in vivo demonstrate that they can also have diverse effects on animal cells and tissues. Particularly interesting is their ability to protect cells against various forms of stress and prevent some detrimental effects of cell aging. For example, human skin fibroblasts cultured in the presence of kinetin or trans-zeatin retain some characteristics of cells of lower passage. Kinetin is even able to increase the lifespan of invertebrates. In this chapter, we review protective effects of cytokinins in animals at molecular, cellular, tissue and organismal levels. We also discuss potential application of cytokinins for the treatment of age-related diseases, including neurodegenerations, inflammatory diseases and disorders caused by aberrant cell proliferation. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2020
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