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New Ligands for Modification of DNA by Osmium Tetroxide Reagents
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SYSNO ASEP 0506683 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title New Ligands for Modification of DNA by Osmium Tetroxide Reagents Author(s) Havran, Luděk (BFU-R) RID, ORCID
Zenka, Martin (BFU-R)
Fojta, Miroslav (BFU-R) RID, ORCIDNumber of authors 3 Source Title XXXVI. Moderní elektrochemické metody. Sborník přednášek. - Ústí nad Labem : Best servis, 2016 / Navrátil T. ; Fojta M. ; Schwarzová K. - ISBN 978-80-905221-4-5 Pages č. 2016 (2016), s. 68-70 Number of pages 3 s. Publication form Print - P Action Moderní elektrochemické metody /36./ Event date 23.05.2016 - 27.05.2016 VEvent location Jetřichovice Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords nucleic-acids ; complexes ; dna ; Osmium tetroxide complexes Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GBP206/12/G151 GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000389898200015 Annotation Besides DNA intrinsic electroactivity, modification of DNA by redox active tags find wide use in electrochemical analysis of DNA interactions and damage. Application of these tags can improve specificity of the analysis. One from utilized labels in this field are complexes of osmium tetroxide with nitrogen ligands, which produce with DNA electroactive covalent adducts. These complexes preferentially react with thymine in single strand DNA. Type of used ligand influence electrochemical behavior forming adducts. In this contribution will be presented results which are acquired by testing of set a new ligands based of quinone and substituted 1, 10-phenanthroline. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2020
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