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Reduction of the DNA at a Pyrolytic Graphite Electrode:Opening of the Second Half of the Potential Window
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SYSNO ASEP 0506589 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Reduction of the DNA at a Pyrolytic Graphite Electrode:Opening of the Second Half of the Potential Window Author(s) Špaček, Jan (BFU-R) ORCID
Daňhel, Aleš (BFU-R) RID, ORCID
Hasoň, Stanislav (BFU-R) RID, ORCID
Hejduková, M. (CZ)
Fojta, Miroslav (BFU-R) RID, ORCIDNumber of authors 5 Source Title XXXVIII. Moderní elektrochemické metody. Sborník přednášek. - Ústí nad Labem : Best Servis, 2018 / Navrátil T. ; Fojta M. ; Schwarzová K. - ISBN 978-80-905221-6-9 Pages č. 2018 (2018), s. 236-239 Number of pages 4 s. Publication form Print - P Action Moderní elektrochemické metody /38./ Event date 21.05.2018 - 25.05.2018 VEvent location Jetřichovice Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords 5-Methyleylosine ; dna ; Electrochemistry ; Electrochemical oxidation Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GA16-01625S GA ČR - Czech Science Foundation (CSF) EF15_003/0000477 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BFU-R - RVO:68081707 UT WOS 000464596500053 Annotation The pyrolytic graphite electrode (PGE) can be used at highly negative potentials, providing reduction signals known from mercury-based electrodes. Use of the negative part of the potential window more than doubled the number of analytically useful signals provided by unlabelled DNA on PGE. It enables selective analysis of all canonical DNA bases,5-methylcytosine and uracil It also allows for distinction of overlapping signals cathodic polarization can selectively ´switch off´ DNA anodic signals and rice versa. Newly observed signals corresponding to oxidation of reduced bases and reduction of oxidized bases are also described. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2020
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