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Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival
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SYSNO ASEP 0505232 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival Author(s) Maounis, N.F. (US)
Dráberová, Eduarda (UMG-J) RID, ORCID
Trakas, N. (GR)
Chorti, M. (GR)
Riga, D. (GR)
Tzannis, K. (GR)
Kanakis, M. (GR)
Voralu, K. (US)
Ellina, E. (GR)
Mahera, E. (GR)
Demonakou, M. (GR)
Lioulias, A. (GR)
Dráber, Pavel (UMG-J) RID, ORCID
Katsetos, C.D. (US)Number of authors 14 Source Title Histology and Histopathology. - : Universidad de Murcia - ISSN 0213-3911
Roč. 34, č. 1 (2019), s. 81-90Number of pages 10 s. Publication form Print - P Language eng - English Country ES - Spain Keywords Gamma-tubulin ; Immunohistochemistry ; Non-small cell lung cancer ; Survival Subject RIV EB - Genetics ; Molecular Biology OECD category Oncology R&D Projects LTAUSA17052 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA17-11898S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMG-J - RVO:68378050 UT WOS 000452158000008 DOI 10.14670/HH-18-027 Annotation Introduction. It has been reported that overexpression and altered compartmentalization of gamma-tubulin may contribute to tumorigenesis and tumor aggressiveness in a variety of human malignancies. We have shown that gamma-tubulin expression and cellular distribution pattern is also altered in non-small cell lung cancer (NSCLC) (Histol. Histopathol. 2012, 27: 11831194). In the present study we examined the relationship between gamma-tubulin expression and patient overall survival (OS). Material and methods. Immunohistochemistry was performed, with well-characterized anti-gamma-tubulin antibodies, on 109 formalin-fixed, paraffin-embedded NSCLC specimens (p-TNM stage I-III). gamma-Tubulin labeling indexes (LIs) were determined, and the association of gamma-tubulin expression with clinicopathological parameters was evaluated. To analyze OS rates according to gamma-tubulin LIs, patients were categorized into three groups: those with low (0-30%), intermediate (31-69%) or high (70-100%) gamma-tubulin LI. Association of clinicopathological parameters and gamma-tubulin with survival were examined using univariate and multivariate Cox regression analysis. Results. No statistically significant association was seen between gamma-tubulin overexpression and histological type, tumor differentiation, p-TNM stage and adenocarcinoma subtyping. Longer survival was observed in the high gamma-tubulin LI group of patients with p-TNM stages II+III when compared to intermediate or low gamma-tubulin LI groups, but the difference was not statistically significant (p=0.066). On the other hand, when combined low and intermediate gamma-tubulin LI groups (p-TNM stages II+III) where compared to high gamma-tubulin LI group, statistically significant longer survival was observed in high gamma-tubulin group (p=0.021). Conclusion. Our findings suggest that level of gamma-tubulin expression may have an impact on patient survival at more advanced NSCLC stages. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2020 Electronic address https://www.hh.um.es/Abstracts/Vol_34/34_1/34_1_81.htm
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