Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats

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SYSNO ASEP	0504234
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats
Author(s)	Mareš, Pavel (FGU-C)_{RID, ORCID} Kubová, Hana (FGU-C)_{RID, ORCID}
Source Title	Epilepsy Research. - : Elsevier - ISSN 0920-1211 Roč. 149, Jan (2019), s. 17-20
Number of pages	4 s.
Language	eng - English
Country	NL - Netherlands
Keywords	status epilepticus ; immature rats ; pentylenetetrazol ; CGP46381
Subject RIV	FH - Neurology
OECD category	Neurosciences (including psychophysiology
R&D Projects	GA15-16605S GA ČR - Czech Science Foundation (CSF)
	GA18-09296S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	FGU-C - RVO:67985823
UT WOS	000456751500004
EID SCOPUS	85056225338
DOI	10.1016/j.eplepsyres.2018.11.001
Annotation	Possible proconvulsant action of GABAB receptor antagonist CGP46381 was studied 3 and 13 days after status epilepticus elicited in 12-day-old rats. GABAA-dependent activity was tested by pentylenetetrazol administration and found different in 15-day-old rats after status epiolepticus but not in the older group. The interaction of the two GABAergic systems should be studied in detail.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2020
Electronic address	https://doi.org/10.1016/j.eplepsyres.2018.11.001

Number of the records: 1