Number of the records: 1  

Advances in Chemical Biology

  1. 1.
    SYSNO ASEP0502878
    Document TypeM - Monograph Chapter
    R&D Document TypeMonograph Chapter
    TitleSmall molecule modulators of Wnt/β-catenin-driven gene expression
    Author(s) Janečková, Lucie (UMG-J)
    Babošová, Oľga (UMG-J)
    Kořínek, Vladimír (UMG-J) RID
    Source TitleAdvances in Chemical Biology. - Praha : OPTIO CZ, 2019 / Bartůněk Petr - ISBN 978-80-88011-03-3
    Pagess. 2-19
    Number of pages15 s.
    Number of copy50
    Number of pages210
    Publication formPrint - P
    Languageeng - English
    CountryCZ - Czech Republic
    KeywordsWnt pathway ; cancer therapy ; small molecule modulators
    Subject RIVEB - Genetics ; Molecular Biology
    OECD categoryCell biology
    R&D ProjectsLO1220 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportUMG-J - RVO:68378050
    AnnotationThe Wnt pathway represents an evolutionarily conserved signaling mechanism that governs transcriptional programs responsible for proper embryonic development and homeostasis of multiple adult organs. In healthy tissues, canonical -catenin-dependent Wnt signaling is indispensable for stem cell maintenance. In contrast, aberrant Wnt pathway activation underlies a number of diseases, most notably various types of solid cancers and leukemia. The Wnt signal-transducing cascade includes multiple components involved in the pathway regulation. In the past 20 years, great effort has been concentrated on discovering and characterizing these components. Additionally, many small molecule compounds that influence the Wnt signaling output have been identified. Wnt signaling inhibitors might be used for improved cancer therapy. On the other hand, as culture media constituents, the Wnt activators can support growth of adult stem cells in vitro. Both of these usages make search for modulators of Wnt signaling an attractive area of biomedical research. In this review, we summarize a number of compounds that were recently shown to effectively modulate Wnt/β-catenin signaling. As our team has identified some of these compounds, the review also focuses on experimental tools and methods used to identify and test small molecule inhibitors of Wnt signaling.
    WorkplaceInstitute of Molecular Genetics
    ContactNikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
    Year of Publishing2019
Number of the records: 1  

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