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Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart
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SYSNO ASEP 0501676 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Optical Mapping Can Reveal Two-Dimensional Morphology of Atrioventricular Insulation in the Foetal Avian Heart Author(s) Olejníčková, Veronika (FGU-C) RID, ORCID, SAI
Janoušek, O. (CZ)
Ronzhina, M. (CZ)
Hejč, J. (CZ)
Zábrodská, E. (CZ)
Kvasilová, A. (CZ)
Sedmera, David (FGU-C) RID, ORCID, SAISource Title Computing in Cardiology 2018, 45. - New York : IEEE, 2018 Number of pages 4 s. Publication form Online - E Action Computing in Cardiology /45./ Event date 23.09.2018 - 26.09.2018 VEvent location Maastricht Country NL - Netherlands Event type WRD Language eng - English Country US - United States Keywords ventricular pre-excitation ; atrio-ventricular re-entry ; embryonic heart ; optical mapping Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery OECD category Cardiac and Cardiovascular systems Institutional support FGU-C - RVO:67985823 UT WOS 000482598700281 EID SCOPUS 85068746861 DOI 10.22489/CinC.2018.055 Annotation Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of the AV junction (AVJ) during prenatal development. However, technical limitations pose challenge to study foetal heart electrophysiology and are hampering understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of retrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during the entire prenatal period. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of ectopic AV electrical continuity was still detected in post-septation foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none were detected on prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling during whole prenatal chicken development and spatiotemporally localise electrically active APs. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2019 Electronic address http://www.cinc.org/cinc-papers-on-line/
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