Nanostructures in Biomedicine: Their Regenerative and toxic properties

0500104 - ÚEM 2019 RIV CZ eng M - Monography Chapter
Filová, Eva - Hefka Blahnová, Veronika
Nanofiber or Microfiber Scaffolds in the Regeneration of Osteochondral Defects.
Nanostructures in Biomedicine: Their Regenerative and toxic properties. Praha 3: Proxima Tisk, s.r.o., 2018 - (Pamula, E.), s. 137-141. ISBN 978-80-906655-7-6
R&D Projects: GA MŠMT(CZ) LO1309
Institutional support: RVO:68378041
Keywords : nanofibers * osteochondral defects * tissue regeneration
OECD category: Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Nanofibers (or nano/microfibers) have been widely studied in tissue regeneration, due to their structure resembling extracellular matrix and biocompatibility. The majority of nanofibers are currently being prepared from biodegradable polymers. They have been used either alone as composite scaffolds, which often combine synthetic and natural polymers, or as hybrid scaffolds. Hybrid scaffolds have better biomechanical properties which can be tailored according to the regenerated tissue, this structure is stable for a defined time. They improve cell adhesion and proliferation, decrease adverse reactions or can serve as a drug delivery system modifying cell proliferation and differentiation and, therefore, tissue regeneration.
Permanent Link: http://hdl.handle.net/11104/0293713