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On the Mechanism of Colloidal Silica Action to Improve Flow Properties of Pharmaceutical Excipients.
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SYSNO ASEP 0499516 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title On the Mechanism of Colloidal Silica Action to Improve Flow Properties of Pharmaceutical Excipients. Author(s) Tran, D.T. (CZ)
Majerová, D. (CZ)
Veselý, M. (CZ)
Kulaviak, Lukáš (UCHP-M) RID, ORCID, SAI
Růžička, Marek (UCHP-M) RID, ORCID, SAI
Zámostný, P. (CZ)Source Title International Journal of Pharmaceutics. - : Elsevier - ISSN 0378-5173
Roč. 556, FEB 10 (2019), s. 383-394Number of pages 12 s. Language eng - English Country NL - Netherlands Keywords colloidal silica ; glidant ; flow properties Subject RIV CI - Industrial Chemistry, Chemical Engineering OECD category Chemical process engineering Institutional support UCHP-M - RVO:67985858 UT WOS 000455968700037 EID SCOPUS 85059591088 DOI 10.1016/j.ijpharm.2018.11.066 Annotation The mechanism of colloidal silica action to improve flow properties of pharmaceutical powders is known to be based on inter-particle force disruption by silica particles adhered to the particle surface. In the present article, the kinetic aspects of this action are investigated, focusing on non-spherical particles of different size. Blends comprising microcrystalline cellulose or calcium hydrogen phosphate dihydrate and colloidal silica were examined using powder rheometer. The blends were formulated to represent effects of particle size, surface texture, colloidal silica loading, and mixing time. Pre-conditioning, shear testing, compressibility, and flow energy measurements were used to monitor flow properties. Components and blends were analyzed using particle size analysis and scanning electron microscopy (SEM), using energy dispersive spectroscopy (EDS) and back-scattered electron (BSE) detection to determine surface particle arrangement. All studied parameters were found to have substantial effects on flow properties of powder blends. Those effects were explained by identifying key steps of colloidal silica action, which were found to proceed at substantially different rates, causing the flow properties change over time being dependent on the blend formulation and the component properties. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2019
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