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Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats
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SYSNO ASEP 0498967 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats Author(s) Horsley, R. R. (CZ)
Páleníček, T. (CZ)
Kolín, Jan (FGU-C)
Valeš, Karel (FGU-C) RID, ORCID, SAISource Title Behavioural Pharmacology. - : Lippincott Williams & Wilkins - ISSN 0955-8810
Roč. 29, č. 6 (2018), s. 530-536Number of pages 7 s. Language eng - English Country US - United States Keywords anxiety ; elevated plus-maze ; ketamine ; microdose ; microdosing ; psilocin ; psychedelic ; rat Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000441142400007 EID SCOPUS 85051256447 DOI 10.1097/FBP.0000000000000394 Annotation Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety. Recently, a trend has developed for long-term intermittent microdosing' (usually one-tenth of a full' active dose), with reports of long-lasting relief from anxiety and related disorders, however, there is no scientific evidence for the efficacy of therapeutic microdosing nor to show its lasting effects. The objective of this study was to test for lasting effects on anxiety in rats after microdosing with ketamine or psilocin. Over 6 days, Wistar rats (N=40) were administered ketamine (0.5 or 3mg/kg), psilocin (0.05 or 0.075mg/kg), or saline on three occasions. A 5-min elevated plus-maze test was conducted 48h after the final drug treatment (n=8). Dependent variables were entries (frequency), spent time (%), and distance traveled (cm) in each zone, as well as total frequency of rears, stretch-attend postures, and head dips. Statistical analyses of drug effects used separate independent one-way analysis of variance and pair-wise comparisons using independent t-tests. Statistical effects were modest or borderline and were most consistent with a mildly anxiogenic profile, which was significant at lower doses, however, this conclusion remains tentative. The lower doses of ketamine and psilocin produced comparable effects (to one another) across each variable, as did the higher doses. This pattern of effects may suggest a common (e.g. neurotransmitter/receptor) mechanism. We conclude that microdosing with hallucinogens for therapeutic purposes might be counter-productive, however, more research is needed to confirm our findings and to establish their translational relevance to clinical psychedelic' therapy. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2019
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