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Alginate matrices for protein delivery - a short review
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SYSNO ASEP 0496666 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Alginate matrices for protein delivery - a short review Author(s) Wawrzyńska, Edyta (UMCH-V) RID, ORCID
Kubies, Dana (UMCH-V) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 67, Suppl. 2 (2018), S319-S334Number of pages 16 s. Language eng - English Country CZ - Czech Republic Keywords protein ; growth factors ; alginate Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemical research methods R&D Projects LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000450606900006 EID SCOPUS 85055856152 Annotation Growth factors are powerful molecules that regulate cellular growth, proliferation, healing, and cellular differentiation. A delivery matrix that incorporates growth factors with high loading efficiencies, controls their release, and maintains bioactivity would be a powerful tool for regenerative medicine. Alginate has several unique properties that make it an excellent platform for the delivery of proteins. Mild gelling conditions can minimize the risk of protein denaturation. Moreover, alginate can serve as protection from degradation until protein release. Various modifications have been proposed to tune alginate binding and release proteins, simultaneously adjusting alginate degradability, mechanical stiffness, swelling, gelation properties and cell affinity. The primary objective of this article is to review the literature related to recent advances in the application of alginate matrices in protein delivery in regenerative medicine. A special emphasis is put on the relevance of delivery of growth factors and chemokine. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2019 Electronic address http://www.biomed.cas.cz/physiolres/pdf/67/67_S319.pdf
Number of the records: 1