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Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis
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SYSNO ASEP 0492350 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis Author(s) Kalous, Jaroslav (UZFG-Y) RID, ORCID
Tětková, Anna (UZFG-Y) ORCID
Kubelka, Michal (UZFG-Y) RID, ORCID
Šušor, Andrej (UZFG-Y) RID, ORCIDArticle number 698 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 19, č. 3 (2018)Number of pages 21 s. Language eng - English Country CH - Switzerland Keywords ERK1/2 ; MAP kinase ; mTOR Subject RIV EB - Genetics ; Molecular Biology OECD category Reproductive biology (medical aspects to be 3) R&D Projects GA15-22765S GA ČR - Czech Science Foundation (CSF) EF15_003/0000460 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UZFG-Y - RVO:67985904 UT WOS 000428309800055 EID SCOPUS 85042787387 DOI 10.3390/ijms19030698 Annotation Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) aktivity, as well as in microtubules organization during meiotic maturation of oocytes, has already been described in detail, rather less attention has been paid to the role of ERK1/2 in the regulation of mRNA translation. However, important data on the role of ERK1/2 in translation during oocyte meiosis have been documented. This review focuses on recent findings regarding the regulation of translation and the role of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR), eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) activity is addressed along with additional focus on the other key players involved in protein translation. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2019
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