Discovery of N-2-(4-Amino-cyclohexyl)-9-cyclopentyl-N-6-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations

GUCKÝ, T., ŘEZNÍČKOVÁ, E., RADOŠOVÁ MUCHOVÁ, T., JORDA, R., KLEJOVÁ, Z., MALÍNKOVÁ, V., BERKA, K., BAZGIER, V., AJANI, H., LEPŠÍK, M., DIVOKÝ, V., KRYŠTOF, V. Discovery of N-2-(4-Amino-cyclohexyl)-9-cyclopentyl-N-6-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. Journal of Medicinal Chemistry. 2018, 61(9), 3855-3869. ISSN 0022-2623. E-ISSN 1520-4804. Available: doi: 10.1021/acs.jmedchem.7b01529