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Anthracycline antibiotics derivate mitoxantrone-Destructive sorption and photocatalytic degradation
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SYSNO ASEP 0488747 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Anthracycline antibiotics derivate mitoxantrone-Destructive sorption and photocatalytic degradation Author(s) Štenglová Netíková, I. R. (CZ)
Petruželka, L. (CZ)
Šťastný, Martin (UACH-T) SAI, RID
Štengl, Václav (UACH-T) RID, ORCID, SAIArticle number e0193116 Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 13, č. 3 (2018)Number of pages 15 s. Language eng - English Country US - United States Keywords anthracycline antibiotics derivate ; nanostructured titanium(IV) oxide Subject RIV CA - Inorganic Chemistry OECD category Inorganic and nuclear chemistry R&D Projects TG02010049 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Institutional support UACH-T - RVO:61388980 UT WOS 000427253500005 EID SCOPUS 85043765456 DOI https://doi.org/10.1371/journal.pone.0193116 Annotation Nanostructured titanium(IV) oxide was used for the destructive adsorption and photocatalytic degradation of mitoxantrone (MTX), a cytostatic drug from the group of anthracycline antibiotics. During adsorption on atitania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1, 4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl) amino)-8-((2-(methylamino)ethyl)amino)anthracene-9, 10-dione, 1, 4-dihydroxy-5, 8-diimi-noanthracene-9, 10(5H, 8H)-dione and 1, 4-dihydroxy-5-imino-8-(methyleneamino)anthra-cene-9, 10(5H, 8H)-dione, were identified. In the case of photocatalytic degradation, only one degradation product after 15 min at m/z 472 was identified. This degradation product corresponded to mitoxantrone dicarboxylic acid, and complete mineralization was attained in one hour. Destructive adsorbent manganese(IV) oxide, MnO 2 , was used only for the destructive adsorption of MTX. Destructive adsorption occurred only for one degradation product, mitoxantrone dicarboxylic acid, against anatase TiO 2 . Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2019
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