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Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?
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SYSNO ASEP 0488661 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats? Author(s) Abbasova, Kenul (FGU-C)
Kubová, Hana (FGU-C) RID, ORCID
Mareš, Pavel (FGU-C) RID, ORCIDSource Title Pharmacological Reports. - : Springer - ISSN 1734-1140
Roč. 70, č. 1 (2018), s. 126-132Number of pages 7 s. Language eng - English Country PL - Poland Keywords status epilepticus ; immature rats ; ifenprodil ; cortical stimulation ; epileptic afterdischarges Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects GAP302/10/0971 GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) GA15-16605S GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LH15032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000428169000020 EID SCOPUS 85040651851 DOI https://doi.org/10.1016/j.pharep.2017.08.012 Annotation Ifenprodil as a specific antagonist of NMDA receptors containing a dominant NR2Bsubunit exhibits age-dependent anticonvulsant action. Possible changes of this action due to status epilepticus (SE) elicited at early stage of development were studied using cortical epileptic afterdischarges (ADs) as a model. Lithium-pilocarpine SE was induced at postnatal day 12 and effects of ifenprodil were studied 3, 6, 9, and 13 days after SE in rat pups with implanted epiduralelectrodes. Controls (LiPAR) received saline instead of pilocarpine. ADs were elicited by low frequency stimulation of sensorimotor cortex. Intensity of stimulation current increased in 18 steps from 0.2 to 15 mA. Ifenprodil (20 mg/kg) was administered intraperitoneally (ip) after the stimulation with 3.5-mA current. Threshold for four different phenomena as well as duration of ADs were evaluated. The threshold for the transition into the limbic type of ADs was higher in 15-day-old SE rats than in LiPAR controls. Opposite difference was found in 18-day-old animals, older rats did not exhibit any difference. Isolated significant changes in total duration of ADs were found after high stimulation intensities. These changes appeared in 18-day-old rats where ADs were shorter in SE than in control LiPAR rats. Changes in ifenprodil action were found only in the first week after SE but not in the second week. Interpretation of the results is complicated by failure of significant differences between SE and LiPAR rats probably due to a high dose of paraldehyde. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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