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Nuclear bodies: news insights into structure and function
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SYSNO ASEP 0487072 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nuclear bodies: news insights into structure and function Author(s) Staněk, David (UMG-J) RID
Fox, A.H. (AU)Number of authors 2 Source Title Current Opinion in Cell Biology. - : Elsevier - ISSN 0955-0674
Roč. 46, léto (2017), s. 94-101Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords rna-binding proteins ; cajal bodies ; smn complex ; human-cells ; in-vivo ; human telomerase ; coiled bodies ; lncrna neat1 ; u1 snrnp ; body Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology Subject RIV - cooperation Genetics ; Molecular Biology R&D Projects GA15-00790S GA ČR - Czech Science Foundation (CSF) LO1419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMG-J - RVO:68378050 UT WOS 000404989900014 DOI 10.1016/j.ceb.2017.05.001 Annotation The cell nucleus contains a number of different dynamic bodies that are variously composed of proteins and generally, but not always, specific RNA molecules. Recent studies have revealed new understanding about nuclear body formation and function in different aspects of nuclear metabolism. Here, we focus on findings describing the role of nuclear bodies in the biogenesis of specific ribonucleoprotein complexes, processing of key mRNAs, and subnuclear sequestration of protein factors. We highlight how nuclear bodies are involved in stress responses, innate immunity and tumorigenesis. We further review organization of nuclear bodies and principles that govern their assembly, highlighting the pivotal role of scaffolding noncoding RNAs, and liquid-liquid phase separation, which are transforming our picture of nuclear body formation. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2018
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