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Injury of the brain and liver capillaries in lethal car accidents
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SYSNO ASEP 0486611 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Injury of the brain and liver capillaries in lethal car accidents Author(s) Makovický, Peter (UMG-J)
Matlach, R. (CZ)
Makovický, P. (SK)
Švecová, Ivana (UMG-J)
Samasca, G. (RO)Number of authors 5 Source Title Revista de Medicina Legala - ISSN 1221-8618
Roč. 25, č. 4 (2017), s. 351-358Number of pages 8 s. Language eng - English Country RO - Romania Keywords shock-wave lithotripsy ; posttraumatic stress symptoms ; blast exposure ; gallbladder ; arteries ; vessels ; bleeding ; shock wave ; veins ; capillaries Subject RIV EB - Genetics ; Molecular Biology OECD category Pathology R&D Projects LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015064 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1509 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMG-J - RVO:68378050 UT WOS 000422835900006 DOI https://doi.org/10.4323/rjlm.2017.351 Annotation The study is reporting about the range of changes in the brain and liver capillaries in lethal automobile collisions. We present five case studies, where there was no compression of the head and abdominal organs, but the cause of death was hypovolemic shock associated with excessive blood loss. During the autopsy we removed tissue samples which were subjected to standard processed in order to permit histological and immunohistochemical examinations. Slices of liver and brain tissue were immunostained for Bcl2L1, GFAP, IL-12, S100 and Vimentin. We found a wide range of changes in this material, with microbleeding, bloodstaining, relaxation of capillaries with release of erythrocytes into the periphery, as well as neuron, axon and supporting glial cells damage. We observed a relationship between the microruptures of brain capillaries and the death of adjacent astrocytes. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2018
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