Number of the records: 1
Omega-3 fatty acids promote fatty acid utilization and production of pro-resolving lipid mediators in alternatively activated adipose tissue macrophages
- 1.
SYSNO ASEP 0485878 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Omega-3 fatty acids promote fatty acid utilization and production of pro-resolving lipid mediators in alternatively activated adipose tissue macrophages Author(s) Rombaldová, Martina (FGU-C) RID, ORCID
Janovská, Petra (FGU-C) RID, ORCID
Kopecký, Jan (FGU-C) RID, ORCID
Kuda, Ondřej (FGU-C) RID, ORCID, SAISource Title Biochemical and Biophysical Research Communications. - : Elsevier - ISSN 0006-291X
Roč. 490, č. 3 (2017), s. 1080-1085Number of pages 6 s. Language eng - English Country US - United States Keywords adipose tissue ; macrophages ; omega-3 PUFA ; fatty acid re-esterification ; lipolysis ; lipid mediators Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition OECD category Endocrinology and metabolism (including diabetes, hormones) R&D Projects GA16-05151S GA ČR - Czech Science Foundation (CSF) LTAUSA17173 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000406820600074 EID SCOPUS 85021702368 DOI https://doi.org/10.1016/j.bbrc.2017.06.170 Annotation It is becoming increasingly apparent that mutual interactions between adipocytes and immune cells are key to the integrated control of adipose tissue inflammation and lipid metabolism in obesity, but little is known about the non-inflammatory functions of adipose tissue macrophages (ATMs) and how they might be impacted by neighboring adipocytes. In the current study we used metabolipidomic analysis to examine the adaptations to lipid overload of M1 or M2 polarized macrophages co-incubated with adipocytes and explored potential benefits of omega-3 polyunsaturated fatty acids (PUFA). Macrophages adjust their metabolism to process excess lipids and M2 macrophages in turn modulate lipolysis and fatty acids (FA) re-esterification of adipocytes. While M1 macrophages tend to store surplus FA as triacylglycerols and cholesteryl esters in lipid droplets, M2 macrophages channel FA toward re-esterification and beta-oxidation. Dietary omega-3 PUFA enhance beta-oxidation in both M1 and M2. Our data document that ATMs contribute to lipid trafficking in adipose tissue and that omega-3 PUFA could modulate FA metabolism of ATMs. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
Number of the records: 1