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Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities

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    0485728 - BFÚ 2018 RIV DE eng J - Journal Article
    Hofmanová, Jiřina - Slavík, J. - Ovesná, P. - Tylichová, Zuzana - Vondráček, Jan - Straková, Nicol - Vaculová, Alena - Cigánek, M. - Kozubík, Alois - Knopfová, L. - Šmarda, J. - Machala, M.
    Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities.
    European Journal of Nutrition. Roč. 56, č. 4 (2017), s. 1493-1508. ISSN 1436-6207. E-ISSN 1436-6215
    R&D Projects: GA ČR GA13-09766S; GA MZd(CZ) NV15-30585A
    Institutional support: RVO:68081707
    Keywords : docosahexaenoic acid * cancer-cells * epithelial-cells
    OECD category: Oncology
    Impact factor: 4.423, year: 2017

    Although beneficial effects of the dietary n-3 docosahexaenoic acid (DHA) or butyrate in colon carcinogenesis have been implicated, the mechanisms of their action are not fully clear. Here, we investigated modulations of composition of individual phospholipid (PL) classes, with a particular emphasis on cardiolipins (CLs), in colon cells treated with DHA, sodium butyrate (NaBt), or their combination (DHA/NaBt), and we evaluated possible associations between lipid changes and cell fate after fatty acid treatment.
    Permanent Link: http://hdl.handle.net/11104/0280680

     
     
Number of the records: 1  

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