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Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines
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SYSNO ASEP 0482386 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines Author(s) Lunova, Mariia (FZU-D) ORCID
Prokhorov, Andriy (FZU-D) ORCID
Jirsa, M. (CZ)
Hof, Martin (UFCH-W) RID, ORCID
Olžyńska, Agnieszka (UFCH-W) RID
Jurkiewicz, Piotr (UFCH-W) RID, ORCID
Kubinová, Šárka (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCID
Dejneka, Alexandr (FZU-D) RID, ORCIDNumber of authors 9 Article number 16049 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 7, Nov (2017), s. 1-16Number of pages 16 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords nanoparticle core stability ; surface functionalization drive ; mTOR signaling pathway ; hepatocellular cell lines Subject RIV BO - Biophysics OECD category Biophysics Subject RIV - cooperation J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry R&D Projects LO1409 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015088 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FZU-D - RVO:68378271 ; UFCH-W - RVO:61388955 UT WOS 000416118900015 EID SCOPUS 85034824356 DOI 10.1038/s41598-017-16447-6 Annotation Specifically designed and functionalized nanoparticles hold great promise for biomedical applications. Yet, the applicability of nanoparticles is critically predetermined by their surface functionalization and biodegradability. Here we demonstrate that amino-functionalized polystyrene nanoparticles (PS-NH2), but not amino- or hydroxyl-functionalized silica particles, trigger cell death in hepatocellular carcinoma Huh7 cells. Importantly, biodegradability of nanoparticles plays a crucial role in regulation of essential cellular processes. Thus, biodegradable silica nanoparticles having the same shape, size and surface functionalization showed opposite cellular effects in comparison with similar polystyrene nanoparticles. At the molecular level, PS-NH2 obstruct and amino-functionalized silica nanoparticles (Si-NH2) activate the mTOR signalling in Huh7 and HepG2 cells. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2018
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