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Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients
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SYSNO ASEP 0480900 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients Author(s) Kroupa, Michal (UEM-P)
Polívková, Z. (CZ)
Rachakonda, S. (DE)
Schneiderová, M. (CZ)
Vodenková, Soňa (UEM-P) ORCID, RID
Buchler, T. (CZ)
Jirásková, Kateřina (UEM-P)
Urbanová, Markéta (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Hemminki, K. (DE)
Kumar, R. (DE)
Vodička, Pavel (UEM-P) RIDSource Title Genes Chromosomes & Cancer. - : Wiley - ISSN 1045-2257
Roč. 57, č. 2 (2018), s. 61-69Number of pages 9 s. Language eng - English Country US - United States Keywords tert promoter mutations ; mutagen sensitivity ; colorectal-cancer ; breast-cancer ; DNA-damage Subject RIV EB - Genetics ; Molecular Biology OECD category Gastroenterology and hepatology R&D Projects NV15-27580A GA MZd - Ministry of Health (MZ) GA15-14789S GA ČR - Czech Science Foundation (CSF) LD14050 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEM-P - RVO:68378041 UT WOS 000418151700002 EID SCOPUS 85041101683 DOI https://doi.org/10.1002/gcc.22508 Annotation Disruption of genomic integrity due to deficient DNA repair capacity and telomere shortening constitute hallmarks of malignant diseases. Incomplete or deficient repair of DNA double-strand breaks (DSB) is manifested by chromosomal aberrations and their frequency reflects inter-individual differences of response to exposure to mutagenic compounds. We have investigated above parameters in blood lymphocytes from patients with breast and colorectal cancer. Our results suggest that altered DSB repair measured by sensitivity towards mutagen in PBL occurs particularly in CRC carcinogenesis. Irrespective of cancer type, telomere shortening may be associated with a decreased capacity to repair DSB. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2019
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