A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties

Bukin, Y. S.; Dzhioev, Y.; Tkachev, S. E.; Kozlova, I.; Paramonov, A. I.; Růžek, Daniel; Qu, Z.; Zlobin, V. I.

doi:https://dx.doi.org/10.1016/j.virusres.2017.06.006

Number of the records: 1

A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties

1.

SYSNO ASEP	0478919
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties
Author(s)	Bukin, Y. S. (RU) Dzhioev, Y. (RU) Tkachev, S. E. (RU) Kozlova, I. (RU) Paramonov, A. I. (RU) Růžek, Daniel (BC-A)_{RID, ORCID} Qu, Z. (CN) Zlobin, V. I. (RU)
Number of authors	8
Source Title	Virus Research. - : Elsevier - ISSN 0168-1702 Roč. 238, JUN 15 (2017), s. 124-132
Number of pages	9 s.
Publication form	Print - P
Language	eng - English
Country	NL - Netherlands
Keywords	tick-borne encephalitis virus ; E protein ; physicochemical properties amino acid residue ; antigen ; antibody
Subject RIV	EE - Microbiology, Virology
OECD category	Virology
Institutional support	BC-A - RVO:60077344
UT WOS	000408077500017
EID SCOPUS	85021694350
DOI	10.1016/j.virusres.2017.06.006
Annotation	This work is dedicated to the study of the variability of the main antigenic envelope protein E among different strains of tick-borne encephalitis virus at the level of physical and chemical properties of the amino acid residues. E protein variants were extracted from then NCBI database. Four amino acid residues properties in the polypeptide sequences were investigated: the average volume of the amino acid residue in the protein tertiary structure, the number of amino acid residue hydrogen bond donors, the charge of amino acid residue lateral radical and the dipole moment of the amino acid residue. These physico-chemical properties are involved in antigen-antibody interactions. As a result, 103 different variants of the antigenic determinants of the tick-borne encephalitis virus E protein were found, significantly different by physical and chemical properties of the amino acid residues in their structure. This means that some strains among the natural variants of tick-borne encephalitis virus can potentially escape the immune response induced by the standard vaccine.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2018

Number of the records: 1