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Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?
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SYSNO ASEP 0475001 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats? Author(s) Tsenov, Grygoriy (FGU-C) RID, ORCID
Kubová, Hana (FGU-C) RID, ORCID
Mareš, Pavel (FGU-C) RID, ORCIDSource Title Neuroscience Letters. - : Elsevier - ISSN 0304-3940
Roč. 644, Mar 22 (2017), s. 1-4Number of pages 4 s. Language eng - English Country IE - Ireland Keywords status epilepticus ; immature rats ; pilocarpine ; lithium chloride ; paraldehyde ; cortical epileptic afterdischarges Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology R&D Projects GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) GAP302/10/0971 GA ČR - Czech Science Foundation (CSF) GA15-16605S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000407529300001 EID SCOPUS 85013790767 DOI 10.1016/j.neulet.2017.02.043 Annotation Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naive animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to na ve control with a progressive prolongation of CxAD. LiCI group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium paraldehyde are similar to na ve controls. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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