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The assembly and function of perinuclear actin cap in migrating cells
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SYSNO ASEP 0474654 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The assembly and function of perinuclear actin cap in migrating cells Author(s) Maninová, Miloslava (MBU-M) RID
Čáslavský, Josef (MBU-M)
Vomastek, Tomáš (MBU-M) RID, ORCIDSource Title Protoplasma - ISSN 0033-183X
Roč. 254, č. 3 (2017), s. 1207-1218Number of pages 12 s. Language eng - English Country AT - Austria Keywords LINC ; Stress fibers ; Focal adhesions Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects GA13-06405S GA ČR - Czech Science Foundation (CSF) Fellowship J. E. Purkyně GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Institutional support MBU-M - RVO:61388971 UT WOS 000399037400008 EID SCOPUS 85009802402 DOI https://doi.org/10.1007/s00709-017-1077-0 Annotation Stress fibers are actin bundles encompassing actin filaments, actin-crosslinking, and actin-associated proteins that represent the major contractile system in the cell. Different types of stress fibers assemble in adherent cells, and they are central to diverse cellular processes including establishment of the cell shape, morphogenesis, cell polarization, and migration. Stress fibers display specific cellular organization and localization, with ventral fibers present at the basal side, and dorsal fibers and transverse actin arcs rising at the cell front from the ventral to the dorsal side and toward the nucleus. Perinuclear actin cap fibers are a specific subtype of stress fibers that rise from the leading edge above the nucleus and terminate at the cell rear forming a dome-like structure. Perinuclear actin cap fibers are fixed at three points: both ends are anchored in focal adhesions, while the central part is physically attached to the nucleus and nuclear lamina through the linker of nucleoskeleton and cytoskeleton (LINC) complex. Here, we discuss recent work that provides new insights into the mechanism of assembly and the function of these actin stress fibers that directly link extracellular matrix and focal adhesions with the nuclear envelope. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2018
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