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Mitochondrial Complex II: At the Crossroads
- 1.0474448 - BTÚ 2018 RIV GB eng J - Journal Article
Bezawork-Geleta, A. - Rohlena, Jakub - Dong, L. - Pacak, K. - Neužil, Jiří
Mitochondrial Complex II: At the Crossroads.
Trends in Biochemical Sciences. Roč. 42, č. 4 (2017), s. 312-325. ISSN 0968-0004. E-ISSN 1362-4326
R&D Projects: GA ČR GA15-02203S; GA ČR(CZ) GA16-12719S; GA ČR GA17-20904S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : GASTROINTESTINAL STROMAL TUMORS * SUCCINATE-DEHYDROGENASE ACTIVITY * ALPHA-TOCOPHERYL SUCCINATE
OECD category: Cell biology
Impact factor: 15.678, year: 2017
Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation in response to various intrinsic and extrinsic stimuli and abnormalities. In this review we discuss recent findings regarding SDH biogenesis, which requires four known assembly factors, and modulation of its enzymatic activity by acetylation, succinylation, phosphorylation, and proteolysis. We further focus on the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations. This review also covers the recent discovery of the role of SDH in inflammation-linked pathologies. Conceivably, SDH is a potential target for several hard-to-treat conditions, including cancer, that remains to be fully exploited.
Permanent Link: http://hdl.handle.net/11104/0271499
Number of the records: 1