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Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake
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SYSNO ASEP 0474132 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake Author(s) Szeiffová Bačová, B. (SK)
Vinczenzová, C. (SK)
Žurmanová, J. (CZ)
Kašparová, Dita (FGU-C)
Knezl, V. (SK)
Egan Beňová, T. (SK)
Pavelka, Stanislav (FGU-C) RID
Soukup, Tomáš (FGU-C) RID
Tribulová, N. (SK)Source Title Histochemistry and Cell Biology. - : Springer - ISSN 0948-6143
Roč. 147, č. 1 (2017), s. 63-73Number of pages 11 s. Language eng - English Country DE - Germany Keywords thyroid hormones ; cardiac arrhythmias ; connexin-43 ; PKC ; red palm oil Subject RIV ED - Physiology OECD category Physiology (including cytology) R&D Projects LH15279 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 7AMB14SK123 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000392063000007 EID SCOPUS 84986253889 DOI 10.1007/s00418-016-1488-6 Annotation We aimed to study the impact of altered thyroid status on myocardial expression of electrical coupling protein connexin-43 (Cx43), the susceptibility of rats to ventricular fibrillation (VF) and the effects of antioxidant-rich red palm oil (RPO). We found that function of the heart was partially normalized by RPO intake, which also enhanced myocardial Cx43 and PKC-epsilon expression as well as increased VF threshold in hyperthyroid male rats. From the results obtained we conclude that there is an inverse relationship between myocardial expression of Cx43, including its functional phosphorylated forms, and susceptibility of male rat hearts to VF in condition of altered thyroid status. RPO intake partly ameliorated adverse changes caused by excess of thyroid hormones. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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