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2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound
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SYSNO ASEP 0473521 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound Author(s) Filippopoulou, K. (GR)
Papaevgeniou, N. (GR)
Lefakia, M. (GR)
Paraskevopoulou, A. (GR)
Biedermann, David (MBU-M) RID, ORCID
Křen, Vladimír (MBU-M) RID, ORCID
Chondrogianni, N. (GR)Source Title Free Radical Biology and Medicine. - : Elsevier - ISSN 0891-5849
Roč. 103, FEB 2017 (2017), s. 256-267Number of pages 12 s. Language eng - English Country US - United States Keywords 2,3-dehydrosilybin A/B ; Anti-aging ; Anti-aggregation Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects LD15081 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 UT WOS 000393014600025 EID SCOPUS 85008152014 DOI 10.1016/j.freeradbiomed.2016.12.042 Annotation Aging is an unavoidable process characterized by gradual failure of homeostasis that constitutes a critical risk factor for several age-related disorders. It has been unveiled that manipulation of various key pathways may decelerate the aging progression and the triggering of age-related diseases. As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-aggregation and anti-oxidation properties that in parallel exhibit negligible side-effects is the main goal in the battle against aging. Here we analyze the role of 2,3-dehydrosilybin A/B (DHS A/B), a minor component of silymarin used in a plethora of dietary supplements. This flavonolignan is well-known for its anti-oxidative and neuroprotective properties, among others. We demonstrate that DHS A/B confers oxidative stress resistance not only in human primary cells but also in the context of a multi-cellular aging model, namely Caenorhabditis elegans (C. elegans) where it also promotes lifespan extension. We reveal that these DHS A/B outcomes are FGT-1 and DAF-16 dependent. We additionally demonstrate the anti-aggregation properties of DHS A/B in human cells of nervous origin but also in nematode models of Alzheimer's disease (AD), eventually leading to decelerated progression of AD phenotype. Our results identify DHS A/B as the active component of silymarin extract and propose DHS A/B as a candidate anti-aging and anti-aggregation compound. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2018
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