Number of the records: 1
Expression of FGFs during early mouse tongue development
- 1.
SYSNO ASEP 0472120 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expression of FGFs during early mouse tongue development Author(s) Du, W. (US)
Procházka, Jan (UMG-J) ORCID
Procházková, Michaela (UMG-J)
Klein, O.D. (US)Number of authors 4 Source Title Gene Expression Patterns. - : Elsevier - ISSN 1567-133X
Roč. 20, č. 2 (2016), s. 81-87Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords Tongue ; FGF ; Expression ; Papilla Subject RIV EB - Genetics ; Molecular Biology Institutional support UMG-J - RVO:68378050 UT WOS 000375160800001 DOI 10.1016/j.gep.2015.12.003 Annotation The fibroblast growth factors (FGFs) constitute one of the largest growth factor families, and several ligands and receptors in this family are known to play critical roles during tongue development. In order to provide a comprehensive foundation for research into the role of FGFs during the process of tongue formation, we measured the transcript levels by quantitative PCR and mapped the expression patterns by in situ hybridization of all 22 Fgfs during mouse tongue development between embryonic days (E) 11.5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme. Our results indicate that FGF signaling regulates tongue development at multiple stages. (C) 2016 Elsevier B.V. All rights reserved. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2017
Number of the records: 1