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Highly potent extranuclear-targeted luminescent iridium(III) antitumor agents containing benzimidazole-based ligands with a handle for functionalization
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SYSNO ASEP 0471978 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Highly potent extranuclear-targeted luminescent iridium(III) antitumor agents containing benzimidazole-based ligands with a handle for functionalization Author(s) Yellol, J. (ES)
Perez, S.A. (ES)
Yellol, G. (ES)
Zajac, Juraj (BFU-R)
Donaire, A. (ES)
Vigueras, G. (ES)
Novohradský, Vojtěch (BFU-R) ORCID
Janiak, C. (GB)
Brabec, Viktor (BFU-R) RID, ORCID
Ruiz, J.A. (ES)Number of authors 10 Source Title Chemical Communications. - : Royal Society of Chemistry - ISSN 1359-7345
Roč. 52, č. 98 (2016), s. 14165-14168Number of pages 4 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords anticancer ; complexes ; ruthenium(ii) Subject RIV BO - Biophysics R&D Projects GA14-21053S GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000390437900022 DOI 10.1039/c6cc07909a Annotation A series of 6 substitutionally inert and luminescent iridium(III) antitumor agents of the type [Ir((CN)-N-boolean AND)(2)((NN)-N-boolean AND)][PF6] containing a benzimidazole (NN)-N-boolean AND ligand with an ester group as a handle for further functionalization has been prepared. They exhibit IC50 values in the high nanomolar range in some ovarian and breast cancer cell lines (approximately 100X more cytotoxic than cisplatin (CDDP) in MDA-MB-231) and are located in the actin cortex predominantly as shown by confocal luminescence microscopy. This discovery could open the door to a new large family of drug bioconjugates with diverse and simultaneous functions. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2017
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