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Pathophysiology of perinatal hypoxic-ischemic encephalopathy – biomarkers, animal models and treatment perspectives
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SYSNO ASEP 0470156 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Pathophysiology of perinatal hypoxic-ischemic encephalopathy – biomarkers, animal models and treatment perspectives Author(s) Riljak, V. (CZ)
Kraf, J. (CZ)
Daryanani, A. (CZ)
Jiruška, Přemysl (FGU-C) RID, ORCID, SAI
Otáhal, Jakub (FGU-C) RID, ORCID, SAISource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 65, Suppl.5 (2016), S533-S545Number of pages 13 s. Language eng - English Country CZ - Czech Republic Keywords hypoxic-ischemic encephalopathy ; excitotoxicity ; oxidative stress ; inflammation ; biomarkers Subject RIV FH - Neurology R&D Projects NV15-33115A GA MZd - Ministry of Health (MZ) GA15-08565S GA ČR - Czech Science Foundation (CSF) GA14-02634S GA ČR - Czech Science Foundation (CSF) LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000392030300002 EID SCOPUS 85010005248 Annotation Hypoxic-ischemic encephalopathy (HIE) is one of the leading pediatric neurological conditions causing long-term disabilities and socio-economical burdens. Nearly 20-50 % of asphyxiated newborns with HIE die within the newborn period and another third will develop severe health consequences and permanent handicaps. HIE is the result of severe systemic oxygen deprivation and reduced cerebral blood flow, commonly occurring in full-term infants. Hypoxic-ischemic changes trigger several molecular and cellular processes leading to cell death and inflammation. Generated reactive oxygen species attack surrounding cellular components resulting in functional deficits and mitochondrial dysfunction. The aim of the present paper is to review present knowledge about the pathophysiology of perinatal hypoxic-ischemic encephalopathy, especially with respect to novel treatment strategies and biomarkers that might enhance early detection of this disorder and thus improve the general outcome of patients. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
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