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MUTANT CyaA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL

SYSNO ASEP	0469250
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	MUTANT CyaA POLYPEPTIDES AND POLYPEPTIDE DERIVATIVES SUITABLE FOR THE DELIVERY OF IMMUNOGENIC MOLECULES INTO A CELL
Author(s)	Šebo, Peter (MBU-M)_{RID, ORCID} Osičková, Adriana (MBU-M)_{RID, ORCID} Mašín, Jiří (MBU-M)_{RID, ORCID} Fayolle, C. (FR) Krůšek, Jan (FGU-C)_{RID, ORCID} Basler, Marek (MBU-M) Leclerc, C. (FR) Osička, Radim (MBU-M)_{RID, ORCID}
Year of issue	2016
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	EP2411513
Date of the patent acceptance	09.11.2016
Name of the patent owner	Institut Pasteur (FR)- Fyziologický ústav AV ČR,v. v. i.- Mikrobiologický ústav AV ČR, v. v. i.
Code of the issuer name	EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/
Current use	B - Patent je využíván na základě uzavřené licenční smlouvy mezi vlastníkem a uživatelem
Language	eng - English
Keywords	Bordetella pertusis ; adenylate cyclase protein
Subject RIV	EE - Microbiology, Virology
Subject RIV - cooperation	Institute of Physiology - Physiology
R&D Projects	GA310/08/0447 GA ČR - Czech Science Foundation (CSF)
	2B06161 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	MBU-M - RVO:61388971 ; FGU-C - RVO:67985823
Annotation	The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2017
Electronic address	https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20161109&DB=&locale=en_EP&CC=EP&NR=2411513B1&KC=B1&ND=4#

Number of the records: 1