Number of the records: 1
Effect of Colloidal Silica on Rheological Properties of Common Pharmaceutical Excipients.
- 1.
SYSNO ASEP 0468966 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of Colloidal Silica on Rheological Properties of Common Pharmaceutical Excipients. Author(s) Majerová, D. (CZ)
Kulaviak, Lukáš (UCHP-M) RID, ORCID, SAI
Růžička, Marek (UCHP-M) RID, ORCID, SAI
Štěpánek, F. (CZ)
Zámostný, P. (CZ)Source Title European Journal of Pharmaceutics and Biopharmaceutics. - : Elsevier - ISSN 0939-6411
Roč. 106, SI (2016), s. 2-8Number of pages 7 s. Action International Granulation Workshop /7./ Event date 29.06.2015 - 03.07.2015 VEvent location Sheffield Country GB - United Kingdom Event type EUR Language eng - English Country NL - Netherlands Keywords powder flow ; cohesion ; glidants Subject RIV CI - Industrial Chemistry, Chemical Engineering R&D Projects GA15-05534S GA ČR - Czech Science Foundation (CSF) Institutional support UCHP-M - RVO:67985858 UT WOS 000382338100002 EID SCOPUS 84969506987 DOI https://doi.org/10.1016/j.ejpb.2016.04.025 Annotation In this work, rheological properties of four common excipients were studied by the FT4 Powder Rheometer, which was used for measuring the compressibility index by a piston and flow properties of the powders by a rotational shear cell. After an initial set of measurements, two excipients were chosen and mixed, in varying amounts, with anhydrous colloidal silicon dioxide (Aerosil 200) used as a glidant. The bulk (conditioned and compressed densities, dynamic (basic flow energy) and shear (friction coefficient, flow factor) properties were determined to find an optimum ratio of the glidant. Simultaneously, the particle size data were obtained using a low-angle laser light scattering (LALLS) system and scanning electron microscopy was performed in order to examine the relationship between the rheological properties and the inner structure of the materials. The optimum of flowability for the mixture composition was found, to correspond to empirical findings known from general literature. In addition the mechanism of colloidal silicone dioxide action to improve flowabitlity was suggested and the hypothesis was confirmed by independent test. New findings represent a progress towards future application of determining the optimum concentration of glidant from the basic characteristics of the powder in the pharmaceutical research and development. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2017
Number of the records: 1