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Capillary electrophoresis with contactless conductivity detection for rapid determination of meldonium in urine
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SYSNO ASEP 0467992 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Capillary electrophoresis with contactless conductivity detection for rapid determination of meldonium in urine Author(s) Šlampová, Andrea (UIACH-O) RID
Kubáň, Pavel (UIACH-O) RID, ORCIDNumber of authors 2 Source Title CECE 2016. 13th International Interdisciplinary Meeting on Bioanalysis. - Brno : Ústav analytické chemie AV ČR, v. v. i., 2016 / Foret František ; Křenková Jana ; Drobníková Iveta ; Klepárník Karel - ISBN 978-80-904959-4-4 Pages s. 234-236 Number of pages 3 s. Publication form Online - E Action CECE 2016. International Interdisciplinary Meeting on Bioanalysis /13./ Event date 17.10.2016 - 19.10.2016 VEvent location Brno Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords meldonium ; capillary electrophoresis-capacitively coupled contactless conductivity detection ; urine Subject RIV CB - Analytical Chemistry, Separation R&D Projects GA16-09135S GA ČR - Czech Science Foundation (CSF) Institutional support UIACH-O - RVO:68081715 Annotation A simple, rapid and cheap capillary electrophoresis-capacitively coupled contactless
conductivity detection (CE-C4D) method for determination of meldonium (MEL) in
urine samples was developed. Sample pretreatment was minimized to dilution of urine
samples with DI water and MEL was determined by CE-C4D in background electrolyte
consisting of 2 M acetic acid (pH 2.3) in ng mL−1 to mg mL−1 concentration range.
Sample-to-sample analysis time was less than 4 min, limit of detection and
quantification was 0.015 and 0.05 μg mL−1, respectively, and the method showed
excellent linearity (r2 ≥ 0.9998), recovery (97.6–99.9%) and intraday as well as interday
repeatability (RSD ≤ 4.7%).Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2017
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