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Hydrogel tissue expanders for stomatology. Part I. methacrylate-based polymers
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SYSNO ASEP 0467563 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hydrogel tissue expanders for stomatology. Part I. methacrylate-based polymers Author(s) Hrib, Jakub (UMCH-V) RID
Širc, Jakub (UMCH-V) RID, ORCID
Lesný, P. (CZ)
Hobzová, Radka (UMCH-V) RID, ORCID
Dušková-Smrčková, Miroslava (UMCH-V) RID, ORCID
Michálek, Jiří (UMCH-V) RID, ORCID
Šmucler, R. (CZ)Article number 12 Source Title Journal of Materials Science-Materials in Medicine. - : Springer - ISSN 0957-4530
Roč. 28, č. 1 (2017), s. 1-8Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords hydrogel ; tissue expander ; methacrylates Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000391394200012 EID SCOPUS 85006355090 DOI https://doi.org/10.1007/s10856-016-5818-y Annotation In order to create a soft tissue surplus, implantable volume expanders are often utilized in dental surgery. Implanted tissue expanders should gradually increase their volume, exerting a constant pressure on the surrounding tissue for weeks. Current tissue expanders are based predominantly on externally inflatable balloons or on osmotically active tissue expanders that use soft hydrogels wrapped in perforated plastic coatings, which limit fluid entry and swelling. We have designed and examined tissue expanders based on the controlled rate expansive hydrogels synthesized from copolymers of selected methacrylates and N-vinylpyrrolidone, cross-linked with a combination of non-degradable (glycol dimethacrylates) and hydrolytically degradable (N,O-dimethacryloylhydroxylamine) crosslinkers. These copolymers have close-to-linear volume expansion rates (up to 6-9 times their original volume) and exert an increasing swelling pressure in vitro. The anesthetic benzocaine has been incorporated into the hydrogels, and kinetic release experiments have shown that most of the drug (90%) was released within 48 h. Our proposed hydrogel expanders are homogeneous and have suitable mechanical properties, thus simplifying the surgical manipulations required. Further studies will be needed to completely evaluate their biocompatibility and tissue response to the implants. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2017
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