0467563 - ÚMCH 2017 RIV GB eng J - Journal Article
Hrib, Jakub - Širc, Jakub - Lesný, P. - Hobzová, Radka - Dušková-Smrčková, Miroslava - Michálek, Jiří - Šmucler, R.
Hydrogel tissue expanders for stomatology. Part I. methacrylate-based polymers.
Journal of Materials Science-Materials in Medicine. Roč. 28, č. 1 (2017), s. 1-8, č. článku 12. ISSN 0957-4530. E-ISSN 1573-4838
R&D Projects: GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61389013
Keywords : hydrogel * tissue expander * methacrylates
OECD category: Polymer science
Impact factor: 2.448, year: 2017 ; AIS: 0.498, rok: 2017
DOI: https://doi.org/10.1007/s10856-016-5818-y

In order to create a soft tissue surplus, implantable volume expanders are often utilized in dental surgery. Implanted tissue expanders should gradually increase their volume, exerting a constant pressure on the surrounding tissue for weeks. Current tissue expanders are based predominantly on externally inflatable balloons or on osmotically active tissue expanders that use soft hydrogels wrapped in perforated plastic coatings, which limit fluid entry and swelling. We have designed and examined tissue expanders based on the controlled rate expansive hydrogels synthesized from copolymers of selected methacrylates and N-vinylpyrrolidone, cross-linked with a combination of non-degradable (glycol dimethacrylates) and hydrolytically degradable (N,O-dimethacryloylhydroxylamine) crosslinkers. These copolymers have close-to-linear volume expansion rates (up to 6-9 times their original volume) and exert an increasing swelling pressure in vitro. The anesthetic benzocaine has been incorporated into the hydrogels, and kinetic release experiments have shown that most of the drug (90%) was released within 48 h. Our proposed hydrogel expanders are homogeneous and have suitable mechanical properties, thus simplifying the surgical manipulations required. Further studies will be needed to completely evaluate their biocompatibility and tissue response to the implants.
Permanent Link: http://hdl.handle.net/11104/0266387