0466564 - ÚMCH 2017 RIV US eng J - Journal Article
Nakamura, H. - Koziolová, Eva - Chytil, Petr - Tsukigawa, K. - Fang, J. - Haratake, M. - Ulbrich, Karel - Etrych, Tomáš - Maeda, H.
Pronounced cellular uptake of pirarubicin versus that of other anthracyclines: comparison of HPMA copolymer conjugates of pirarubicin and doxorubicin.
Molecular Pharmaceutics. Roč. 13, č. 12 (2016), s. 4106-4115. ISSN 1543-8384. E-ISSN 1543-8392
R&D Projects: GA ČR(CZ) GA15-02986S; GA MŠMT(CZ) LO1507; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:AV ČR,Japan Society for the Promotion of Science(CZ) JSPS-16-05
Program: Bilaterální spolupráce
Institutional support: RVO:61389013
Keywords : HPMA polymer conjugate * pirarubicin (THP) * doxorubicin (DOX)
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.440, year: 2016

Many conjugates of water-soluble polymers with biologically active molecules were developed during the last two decades. Although, therapeutic effects of these conjugates are affected by the properties of carriers, the properties of the attached drugs appear more important than the same carrier polymer in this case. Pirarubicin (THP), a tetrahydropyranyl derivative of doxorubicin (DOX), demonstrated more rapid cellular internalization and potent cytotoxicity than DOX. Here, we conjugated the THP or DOX to N-(2-hydroxypropyl)methacrylamide copolymer via a hydrazone bond.
Permanent Link: http://hdl.handle.net/11104/0266313