Number of the records: 1
Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum
- 1.
SYSNO ASEP 0466479 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum Author(s) Franco, R. (ES)
Casadó-Anguera, V. (ES)
Muňoz, A. (ES)
Petrovič, Miloš (FGU-C)
Navarro, G. (ES)
Moreno, E. (ES)
Lanciego, J. L. (ES)
Labandeira-García, J. L. (ES)
Cortés, A. (ES)
Casadó, V. (ES)Source Title Molecular Neurobiology. - : Springer - ISSN 0893-7648
Roč. 53, č. 8 (2016), s. 5436-5445Number of pages 10 s. Language eng - English Country US - United States Keywords lateralization ; basal ganglia ; G-protein-coupled receptor dimer ; dyskinesia ; 6-hydroxydopamine Subject RIV ED - Physiology Institutional support FGU-C - RVO:67985823 UT WOS 000382871100033 EID SCOPUS 84944706449 DOI https://doi.org/10.1007/s12035-015-9468-8 Annotation Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson's disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D-1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from na < ve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D-1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
Number of the records: 1