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Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies
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SYSNO ASEP 0463618 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies Author(s) Podholová, K. (CZ)
Plocek, V. (CZ)
Rešetárová, Stanislava (MBU-M) RID
Kučerová, H. (CZ)
Hlaváček, Otakar (MBU-M) RID, ORCID
Váchová, Libuše (MBU-M) RID, ORCID
Palková, Z. (CZ)Source Title OncoTarget. - : Impact Journals LLC - ISSN 1949-2553
Roč. 7, č. 13 (2016), s. 15299-15314Number of pages 16 s. Language eng - English Country US - United States Keywords mitochondrial retrograde signaling ; development and differentiation ; ageing and longevity Subject RIV EE - Microbiology, Virology R&D Projects GA15-08225S GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EE2.3.30.0003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support MBU-M - RVO:61388971 UT WOS 000375692900004 EID SCOPUS 84971655111 DOI 10.18632/oncotarget.8084 Annotation Mitochondrial retrograde signaling mediates communication from altered mitochondria to the nucleus and is involved in many normal and pathophysiological changes, including cell metabolic reprogramming linked to cancer development and progression in mammals. The major mitochondrial retrograde pathway described in yeast includes three activators, Rtg1p, Rtg2p and Rtg3p, and repressors, Mks1p and Bmh1p/Bmh2p. Using differentiated yeast colonies, we show that Mks1p-Rtg pathway regulation is complex and includes three branches that divergently regulate the properties and fate of three specifically localized cell subpopulations via signals from differently altered mitochondria. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2017
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