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High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor
- 1.0463591 - ÚMCH 2017 RIV CZ eng J - Journal Article
Kostka, Libor - Etrych, Tomáš
High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor.
Physiological Research. Roč. 65, Suppl. 2 (2016), S179-S190. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LO1507
Institutional support: RVO:61389013
Keywords : nanotherapeutics * pH responsive * HPMA copolymers
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 1.461, year: 2016
http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S179.pdf
In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecularweight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.
Permanent Link: http://hdl.handle.net/11104/0264463
Number of the records: 1