N-15-labelled pyrazines of triterpenic acids

0460853 - ÚEB 2017 RIV HU eng J - Journal Article
Vlk, M. - Mičolová, P. - Urban, M. - Kvasnica, Miroslav - Šaman, David - Šarek, J.
N-15-labelled pyrazines of triterpenic acids.
Journal of Radioanalytical and Nuclear Chemistry. Roč. 308, č. 2 (2016), s. 733-739. ISSN 0236-5731. E-ISSN 1588-2780
R&D Projects: GA ČR GJ15-08202Y; GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LO1204
Grant - others:GA MŠk(CZ) LK21310; GA TA ČR(CZ) TA03010027; CTU(CZ) SGS15/094/OHK4/1T/14
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : N-15 * Triterpenic acid * Isotopic labelling
Subject RIV: CC - Organic Chemistry
Impact factor: 1.282, year: 2016

Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC50 in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seven triterpenoid skeletal types along with their N-15 labelled analogs. In this work, we present the synthesis and characterization of the target N-15 labelled pyrazines. Currently, these compounds are being studied in complex metabolic studies.
Permanent Link: http://hdl.handle.net/11104/0260829