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Dual inhibition of nitric oxide and prostaglandin E2 production by polysubstituted 2-aminopyrimidines
- 1.0459500 - ÚEM 2017 RIV NL eng J - Journal Article
Zídek, Zdeněk - Kverka, Miloslav - Dusilová, Adéla - Kmoníčková, Eva - Jansa, Petr
Dual inhibition of nitric oxide and prostaglandin E2 production by polysubstituted 2-aminopyrimidines.
Nitric Oxide-Biology and Chemistry. Roč. 57, jul (2016), s. 48-56. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA ČR(CZ) GAP303/12/0172
Institutional support: RVO:68378041 ; RVO:61388963
Keywords : pyrimidines * nitric oxide * prostaglandin E-2
Subject RIV: FR - Pharmacology ; Medidal Chemistry; CC - Organic Chemistry (UOCHB-X)
Impact factor: 4.181, year: 2016
Novel derivatives of pyrimidine inhibit production of inflammatory mediators such as prostaglandin E2 (PGE2) and nitric oxide (NO). A tight dependence of the suppressive activities depend tightly on their chemical structure. No significant correlation between the extent of PGE2 and NO production has been observed. The NO-inhibitory potential of pyrimidines was stronger than that of non-steroidal antiinflammatory drugs aspirin and indomethacin. The PGE2-inhibitory activity was about the same as that of aspirin, but weaker as compared to indomethacin.
Permanent Link: http://hdl.handle.net/11104/0259692
Number of the records: 1