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From Functionalized Nanostructures Towards Engineered Macrostructures
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SYSNO ASEP 0459255 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Stem Cell Treatment in Amyotrophic Lateral Sclerosis Author(s) Forostyak, Serhiy (UEM-P) RID, ORCID
Syková, Eva (UEM-P) RIDSource Title From Functionalized Nanostructures Towards Engineered Macrostructures. - Jindřichův Hradec : Epika, 2015 / Caruana Carmel ; Horník Jakub - ISBN 978-80-88113-20-1 Pages s. 61-73 Number of pages 13 s. Number of pages 176 Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords amyotrophic lateral sclerosis ; neurodegenerative disorders ; mesenchymal stromal cells Subject RIV FP - Other Medical Disciplines R&D Projects LO1309 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEM-P - RVO:68378041 Annotation Amyotrophic lateral sclerosis (ALS) is a largely sporadic progressive neurodegenerative disease affecting upper and lower motor neurons (MNs) and specific etiology that is not completely understood. Up to now, there is no clinically relevant treatment available for ALS. The novel therapeutic strategies should aim at neuroprotection, stimulation of intrinsic neurogenesis and replacement of affected neural cells. These could be achieved by application of powerful modern therapeutic methods such as gene therapy, transplantation of different types of engineered and non-engineered stem cells. Cell-based therapies could facilitate either restoration/substitution or the preservation of MNs. Special attention has been paid to treatment with autologous stem cells, as the most promising approach to the treatment of ALS patients. This review summarises the progress made in translating to the patients' bedside the results achieved from in vivo preclinical studies. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2017
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