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Cholesterol and fat lowering with hydrophobic polysaccharide derivatives
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SYSNO ASEP 0457794 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cholesterol and fat lowering with hydrophobic polysaccharide derivatives Author(s) Čopíková, J. (CZ)
Taubner, T. (CZ)
Tůma, J. (CZ)
Synytsya, A. (CZ)
Dušková, Dagmar (UZFG-Y)
Marounek, Milan (UZFG-Y) RIDSource Title Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 116, č. 1 (2015), s. 207-214Number of pages 8 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords hydrophobically modified polysaccharides ; structure ; thermal analysis Subject RIV CE - Biochemistry Institutional support UZFG-Y - RVO:67985904 UT WOS 000344871200027 EID SCOPUS 84910668823 DOI 10.1016/j.carbpol.2014.05.009 Annotation Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2016
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