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Can Nucleoli Be Markers of Developmental Potential in Human Zygotes?
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SYSNO ASEP 0455801 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Can Nucleoli Be Markers of Developmental Potential in Human Zygotes? Author(s) Fulka, Helena (UMG-J)
Kyogoku, H. (JP)
Zatsepina, O. (RU)
Langerova, A. (CZ)
Fulka, J. (CZ)Source Title Trends in Molecular Medicine. - : Elsevier - ISSN 1471-4914
Roč. 21, č. 11 (2015), s. 663-672Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords human zygotes ; developmental potential ; nucleoli Subject RIV EB - Genetics ; Molecular Biology Institutional support UMG-J - RVO:68378050 ; UZFG-Y - RVO:67985904 UT WOS 000365059200001 DOI 10.1016/j.molmed.2015.09.005 Annotation In 1999, Tesarik and Greco reported that they could predict the developmental potential of human zygotes from a single static evaluation of their pronuclei. This was based on the distribution and number of specific nuclear organelles - the nucleoli. Recent studies in mice show that nucleoli play a key role in parental genome restructuring after fertilization, and that interfering with this process may lead to developmental failure. These studies thus support the Tesarik-Greco evaluation as a potentially useful method for selecting high-quality embryos in human assisted reproductive technologies. In this opinion article we discuss recent evidence linking nucleoli to parental genome reprogramming, and ask whether nucleoli can mirror or be used as representative markers of embryonic parameters such as chromosome content or DNA fragmentation. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2016
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