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Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide
- 1.0455314 - ÚOCHB 2016 RIV IT eng J - Journal Article
Harmatha, Juraj - Vokáč, Karel - Buděšínský, Miloš - Zídek, Zdeněk - Kmoníčková, Eva
Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide.
Fitoterapia. Roč. 107, Dec (2015), s. 90-99. ISSN 0367-326X. E-ISSN 1873-6971
R&D Projects: GA ČR GA305/07/0061
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : sesquiterpene lactones * guaianolides * trilobolide derivatives * nitric oxide * cytokines * immunoactivity
Subject RIV: CC - Organic Chemistry
Impact factor: 2.408, year: 2015
Search for compounds with preserved immunobiological properties and decreased cytotoxicity led us to transform some structural features of trilobolide, particularly those related to their side chain functionality. For this reason, it was prepared over 20 various deacylated, acyl modified, or relactonized derivatives of trilobolide. Their immunobiological effects were screened in vitro using the rat peritoneal cells primed with lipopolysaccharide. Secretion of interferon-gamma (IFN-gamma), interleukins (IL) IL-1beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) were determined by ELISA, and nitric oxide (NO) production by Griess reagent.
Permanent Link: http://hdl.handle.net/11104/0255933
Number of the records: 1