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Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer
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SYSNO ASEP 0451362 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer Author(s) McCullough, L. E. (US)
Eng, S. M. (US)
Bradshaw, P. T. (US)
Cleveland, R. J. (US)
Steck, S. E. (US)
Terry, M. B. (US)
Shen, J. (US)
Crew, K.D. (US)
Rössner ml., Pavel (UEM-P) RID, ORCID
Ahn, J. (US)
Ambrosone, Ch.B. (US)
Teitelbaum, S. L. (US)
Neugut, A. I. (US)
Santella, R. M. (US)
Gammon, M. D. (US)Number of authors 15 Source Title Annals of Epidemiology. - : Elsevier - ISSN 1047-2797
Roč. 25, č. 4 (2015), s. 263-269Number of pages 7 s. Language eng - English Country US - United States Keywords breast cancer ; body mass index ; oxidative stress ; DNA repair ; Epidemiology Subject RIV EB - Genetics ; Molecular Biology Institutional support UEM-P - RVO:68378041 UT WOS 000352118400009 EID SCOPUS 84925259343 DOI 10.1016/j.annepidem.2015.01.009 Annotation We hypothesized that genetic variation in DNA repair and oxidative stress pathways may modify the obesity-postmenopausal breast cancer association. We observed multiplicative interactions (P ≤ 0.05) for eight gene polymorphisms in DNA repair and oxidative stress pathways for breast cancer risk. We conclude that obesity may be particularly deleterious for postmenopausal BC development in the presence of biologically plausible DNA repair or oxidative stress genotypes. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2016
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