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Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer
- 1.0451362 - ÚEM 2016 RIV US eng J - Journal Article
McCullough, L. E. - Eng, S. M. - Bradshaw, P. T. - Cleveland, R. J. - Steck, S. E. - Terry, M. B. - Shen, J. - Crew, K.D. - Rössner ml., Pavel - Ahn, J. - Ambrosone, Ch.B. - Teitelbaum, S. L. - Neugut, A. I. - Santella, R. M. - Gammon, M. D.
Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer.
Annals of Epidemiology. Roč. 25, č. 4 (2015), s. 263-269. ISSN 1047-2797. E-ISSN 1873-2585
Institutional support: RVO:68378041
Keywords : breast cancer * body mass index * oxidative stress * DNA repair * Epidemiology
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.335, year: 2015
We hypothesized that genetic variation in DNA repair and oxidative stress pathways may modify the obesity-postmenopausal breast cancer association. We observed multiplicative interactions (P ≤ 0.05) for eight gene polymorphisms in DNA repair and oxidative stress pathways for breast cancer risk. We conclude that obesity may be particularly deleterious for postmenopausal BC development in the presence of biologically plausible DNA repair or oxidative stress genotypes.
Permanent Link: http://hdl.handle.net/11104/0252844
Number of the records: 1