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Nano-structured and functionalized surfaces for cytocompatibility improvement and bactericidal action
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SYSNO ASEP 0449225 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nano-structured and functionalized surfaces for cytocompatibility improvement and bactericidal action Author(s) Slepička, P. (CZ)
Kasálková-Slepičková, N. (CZ)
Siegel, J. (CZ)
Kolská, Z. (CZ)
Bačáková, Lucie (FGU-C) RID, ORCID
Švorčík, V. (CZ)Source Title Biotechnology Advances. - : Elsevier - ISSN 0734-9750
Roč. 33, 6 Part 2 (2015), s. 1120-1129Number of pages 10 s. Language eng - English Country US - United States Keywords polymers ; surface modification ; cell-material interaction ; tissue engineering Subject RIV JJ - Other Materials R&D Projects GBP108/12/G108 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000362380100009 EID SCOPUS 84942568569 DOI https://doi.org/10.1016/j.biotechadv.2015.01.001 Annotation Not only surface chemistry has an effect on material biological response, surface structures of different morphology can be constructed to guide a desirable biological outcome. Nano-patterned material surfaces have been tested with the aim of how surface geometry and physical properties on a micro- and nano-scale can effect cellular response and influence cell adhesion and proliferation. Biological functionality of solid state substrates was significantly improved by the irradiation of material with plasma discharge or laser treatment. Commonly used “artificial” polymers were treated with the aim of biocompatibility improvement. Surface physico-chemical properties of treated surfaces were determined. The enhancement of adhesion and proliferation of cells on modified substrates was investigated in vitro. Bacterial action of noble metal nano-particles (e.g. Au, Ag) on polymers was characterized. The influence of metal nano-particle grafting by using metal nano-particle suspension prepared by “green” methods was determined. Micro. And nano-patterned surfaces can be constructed as tissue scaffolds with specific functions regarding cell adhesion and proliferation or potential biosensor applications Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2016
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