Molecular and cellular approach in the study of antioxidant/pro-oxidant properties of Micromeria croatica (Pers.) Schott

0447386 - ÚEB 2016 RIV GB eng J - Journal Article
Šamec, D. - Grúz, Jiří - Durgo, K. - Kremer, D. - Kosalec, I. - Žulj, L.V. - Martinez, S. - Salopek-Sondi, B. - Piljac-Žegarac, J.
Molecular and cellular approach in the study of antioxidant/pro-oxidant properties of Micromeria croatica (Pers.) Schott.
Natural Product Research. Roč. 29, č. 18 (2015), s. 1770-1774. ISSN 1478-6419. E-ISSN 1478-6427
R&D Projects: GA MŠMT LK21306
Institutional support: RVO:61389030
Keywords : antioxidant * cytotoxicity * Micromeria croatica (Pers.) Schott
Subject RIV: EF - Botanics
Impact factor: 1.057, year: 2015

Phytochemical composition and antioxidant activity of three wild populations of endemic Illyric-Balcanic species Micromeria croatica (Pers.) Schott have been evaluated with respect to plant organ and growing location. Multivariate analysis (principal component analysis) was performed to visualise (dis-)similarity among samples and identify the correlations between phytochemical variables that explain the most variability. The tested leaf extract from Bai kuk locality exhibited protective effects against reactive oxygen species-induced damage of DNA and inhibition of lipid peroxidation, while it caused oxidative degradation of protein in the bovine serum albumin assay at higher concentrations. This extract also exhibited cytotoxic activity and facilitated the formation of reactive oxygen species in the HEp2 cell line, in a dose-dependent manner.
Permanent Link: http://hdl.handle.net/11104/0249238